27 December 2024 | DOI: 10.1007/s00406-024-01944-3
In this article, the Psych-STRATA project is presented: a multidisciplinary initiative aimed at improving the early identification and treatment of treatment-resistant psychiatric disorders, including schizophrenia, bipolar disorder, and major depressive disorder. The project takes a comprehensive approach involving the identification of genetic and clinical biomarkers, testing early intensified pharmacological treatment in a randomized controlled trial, and developing machine learning models for personalized therapy. A shared decision-making framework, including a mental health board and digital tools is implemented, alongside patient empowerment efforts. Finally, drug repurposing and AI-driven treatment recommendations aim to advance personalized, evidence-based psychiatric care.
