A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness


Our publications, clinical studies, reports and press releases.

Polygenic risk scores of lithium response and treatment resistance in major depressive disorder

September 28, 2023

 | Publication

In this article, the authors describe an increased genetic load for lithium treatment response in patients who suffer treatment-resistant depression (TRD) when compared to depressive patients without TRD (they respond well to antidepressant pharmacological treatment). On the other hand, TRD and non-TRD patients did not show differences regarding the genetic load for antidepressant treatment response. Taken together, these results describe the existence of a genetic profile of lithium-sensitivity in TRD that could explain the efficacy of lithium to treat TRD.

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

January 15, 2023

 | Publication

In this article, the authors observe that the genetic load for schizophrenia is associated with the highest clozapine dose in patients who suffer schizophrenia. It is noteworthy to mention that these researchers replicated this finding in 3 independent samples, the gold standard when it comes to validate the results of a genetic study.