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Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

January 15, 2023

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15 January 2023 | DOI: 10.1016/j.biopsych.2022.07.014

In this article, the authors observe that the genetic load for schizophrenia is associated with the highest clozapine dose in patients who suffer schizophrenia. It is noteworthy to mention that these researchers replicated this finding in 3 independent samples, the gold standard when it comes to validate the results of a genetic study. Likewise, those patients with the highest genetic load for schizophrenia had a higher probability to take clozapine doses over 600 mg/day. The authors suggest that the genetic load for schizophrenia might contribute (together with other predictors) to models/tools to guide therapeutic decisions in cohorts of patients with treatment-resistant schizophrenia.

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