Int J Neuropsychopharmacol. 2025 May 9;28(5):pyaf025
DOI: 10.1093/ijnp/pyaf025. PMID: 40255203 PMCID: PMC12084835
Stefano Comai, Mirko Manchia, Marta Bosia, Alessandro Miola, Sara Poletti, Francesco Benedetti, Sofia Nasini, Raffaele Ferri, Dan Rujescu, Marion Leboyer, Julio Licinio, Bernhard T Baune, Alessandro Serretti
In this review, the authors discuss the progress and the hurdles for the implementation of multimodal approaches for personalized treatment approaches in psychiatry. In this review, current status in the research of biological, clinical, and environmental predictors in schizophrenia, bipolar disorder, and major depression. Most recent findings in neuroimaging, EEG, proteomics, circadian biology, and genetics are discussed. The authors conclude that, despite the challenges for its implementation, precision psychiatry holds promise for the improvement of treatment effectiveness that would lead to better outcomes for these patients.
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