Clin Epigenetics. 2024 Jul 17;16(1):93.
DOI: 10.1186/s13148-024-01704-z. PMID: 39020437
Rosana Carvalho Silva, Paolo Martini, Christa Hohoff, Stefania Mattevi, Marco Bortolomasi, Maria Abate, Valentina Menesello, Massimo Gennarelli, Bernhard T Baune, Alessandra Minelli
Electroconvulsive therapy (ECT) has been shown to be beneficial for patients with treatment-resistant depression (TRD). However very little is known about the biological underpinnings of this intervention. In order to obtain mechanistic insight on the effects of ECT, an epigenome-wide analysis was carried out 32 TRD patients who underwent ECT sessions. ECT-associated methylation changes were observed in several regions of the genome, some of them implicated in inflammatory/immune processes. This pilot study provides preliminary evidence of the epigenetic changes associated with ECT and confirms the role of inflammation and immune response in TRD.
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